Question of the Week # 133

Q133] A 60 year old woman is on clopidogrel therapy and is also taking ginkgo biloba. By altering which of the following does Ginkgo potentiate the effect of clopidogrel? ?

a] Bleeding time

b] Clotting time

c] Reduction of Factor V and VII

d) Displaces clopidogrel from protein binding sites

e) Thrombin time

8 Responses

  1. c- prothrombin time

  2. e-prothrombin time

  3. A.
    Ginko inhibits platelet aggregation like aspirin so it should prolong BT
    Not sure of any other mechanism of action ascribed to ginko causing bleeding.

  4. aaa

  5. a

  6. A – Bleeding time. Gingko Bilboa (B for bleeding time) always remember!

    • It has only potentiation effect on other medications action of increasing bleeding so answer A=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000722/

  7. A: Bleeding time. Ginkgo biloba inhibit platelet inhibiting factor and prevent platelet aggregation. prolong bleeding time.

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